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The dosing range of serotonin precursors needed for the individual patient to achieve proper balance with l-dopa administration appears to be in a relatively narrow range with some of the side effects being displayed if the serotonin is either too high or too low.

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Worley Brown Endowed Chair in Neurology at Emory University, where he also serves as Director, Movement Disorders Program; Professor, Department of Neurology; Vice-Chairman for Clinical Affairs, Department of Neurology; Medical Director, American Parkinson Disease Association (APDA) Information and Referral Center; Co-Director, APDA Advanced Center for Parkinson Research; and Affiliate Scientist, Division of Neurobiology, Yerkes Regional Primate Research Center.

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Burke ( 14) advocated dopamine antagonist treatment ("suppression") for either (a) severe generalized tardive dystonia causing muscle pain or muscle damage (with elevated CPK), or (b) instances where other drugs have failed.

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Synthetic dopamine agonists such as ropinirole, pramiprexole, pergolide, and bromocriptine can be used instead of or alongside L-dopa to manage motor symptoms of PD.

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